Ontology highlight
ABSTRACT:
SUBMITTER: Fang W
PROVIDER: S-EPMC4322961 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Oncotarget 20141201 23
PD-L1 expression is a feature of Epstein-Barr virus (EBV) associated malignancies such as nasopharyngeal carcinoma (NPC). Here, we found that EBV-induced latent membrane protein 1 (LMP1) and IFN-γ pathways cooperate to regulate programmed cell death protein 1 ligand (PD-L1). Expression of PD-L1 was higher in EBV positive NPC cell lines compared with EBV negative cell lines. PD-L1 expression could be increased by exogenous and endogenous induction of LMP1 induced PD-L1. In agreement, expression o ...[more]