Unknown

Dataset Information

0

PD-L1 predicts poor prognosis for nasopharyngeal carcinoma irrespective of PD-1 and EBV-DNA load.


ABSTRACT: Programmed death-1 (PD-1) is an immunosuppressive receptor functionally bound with programmed death-ligand 1 (PD-L1), which has been reported in various malignancies. However, only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). In this study, we aim to investigate alterations in PD-1/PD-L1 by using immunohistochemistry analysis in a cohort of consecutively enrolled NPC patients (n?=?99). To further analyse the correlation between PD-1/PD-L1 and factors involved in clinico-pathology, haematologic biomarkers, EBV-DNA load and outcomes, we collected clinical data for statistical analysis. We observed that lower haemoglobin (HB) and Body Mass Index (BMI) levels were associated with high levels of PD-L1 staining in NPC patients. Importantly, our results suggested that PD-L1 might be a negative indicator for NPC patients. In contrast, a correlation between the PD-1/PD-L1 level and EBV load was not identified. Moreover, PD-1 positivity was suggested to not be significantly correlated with clinical outcomes. Taken together, our results revealed that PD-L1 might be a potential prognostic biomarker for NPC patients. However, further studies are needed to clarify the underlying mechanism of EBV status in the immunosuppression process induced by the PD-1/PD-L1 axis.

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5335261 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

PD-L1 predicts poor prognosis for nasopharyngeal carcinoma irrespective of PD-1 and EBV-DNA load.

Zhou Yajuan Y   Shi Dingbo D   Miao Jingjing J   Wu Haijun H   Chen Jiewei J   Zhou Xiaoyi X   Hu Desheng D   Zhao Chong C   Deng Wuguo W   Xie Conghua C  

Scientific reports 20170303


Programmed death-1 (PD-1) is an immunosuppressive receptor functionally bound with programmed death-ligand 1 (PD-L1), which has been reported in various malignancies. However, only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). In this study, we aim to investigate alterations in PD-1/PD-L1 by using immunohistochemistry analysis in a cohort of consecutively enrolled NPC patients (n = 99). To further analyse the correlation between PD-1/P  ...[more]

Similar Datasets

| S-EPMC5503590 | biostudies-literature
| S-EPMC7057441 | biostudies-literature
| S-EPMC4816273 | biostudies-literature
| S-EPMC8425204 | biostudies-literature
| S-EPMC4322961 | biostudies-literature
| S-EPMC2958949 | biostudies-literature
| S-EPMC4941359 | biostudies-literature
| S-EPMC9357606 | biostudies-literature
| S-EPMC5884219 | biostudies-literature
| S-EPMC9569432 | biostudies-literature