The cellular origin of laminin determines its role in blood pressure regulation.
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ABSTRACT:
SUBMITTER: Yao Y
PROVIDER: S-EPMC4323860 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
The cellular origin of laminin determines its role in blood pressure regulation.
Yao Yao Y Norris Erin H EH Strickland Sidney S
Cellular and molecular life sciences : CMLS 20140913 5
Laminin of different cellular sources has distinct functions. In addition to vascular smooth muscle cells (SMCs), aorta also contains a small population of nestin(+) cells, whose function remains unknown. This study investigates the role of SMC- and nestin(+) cell-derived laminin in blood pressure (BP) regulation and SMC contractibility. Using mice with laminin deficiency in SMCs (SKO) or nestin(+) cells (NKO), we examined laminin-dependent changes in BP. Contractile protein expression was reduc ...[more]
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