Ontology highlight
ABSTRACT:
SUBMITTER: Moriwaki K
PROVIDER: S-EPMC4324020 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Moriwaki Kenta K Bertin John J Gough Peter J PJ Chan Francis Ka-Ming FK
Journal of immunology (Baltimore, Md. : 1950) 20150107 4
Caspase 8, the initiator caspase for death receptor-induced apoptosis, functions as a negative regulator of receptor interacting protein kinase 3 (RIPK3), an essential factor for TNF-, TLR3-, and TLR4-induced necroptosis. In certain situations, caspase 8 can also participate in pro-IL-1β processing. However, the biochemical complex that mediates caspase 8-mediated processing is not defined. In this study, we show that RIPK3 is crucial for caspase 1- and caspase 8-mediated pro-IL-1β and pro-IL-18 ...[more]