Ontology highlight
ABSTRACT:
SUBMITTER: Guldner IH
PROVIDER: S-EPMC4324098 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Guldner Ian H IH Zhang Siyuan S
Integrative biology : quantitative biosciences from nano to macro 20150201 2
The crosstalk between tumor cells and cells of the tumor stroma dictate malignant progression and represent an intriguing and viable anticancer therapeutic target. The successful development of therapeutics targeting tumor-stroma interactions is tied to the insight provided by basic research on such crosstalk. Tumor-stroma interactions can be transient and dynamic, and they occur within defined spatiotemporal contexts among genetically and compositionally heterogeneous populations of cells, yet ...[more]