Ontology highlight
ABSTRACT:
SUBMITTER: Rasson AS
PROVIDER: S-EPMC4324353 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Rasson Amy S AS Bois Justin S JS Pham Duy Stephen L DSL Yoo Haneul H Quinlan Margot E ME
Journal of molecular biology 20140916 4
The most recently identified class of actin nucleators, WASp homology domain 2 (WH2) nucleators, use tandem repeats of monomeric actin-binding WH2 domains to facilitate actin nucleation. WH2 domains are involved in a wide variety of actin regulatory activities. Structurally, they are expected to clash with interprotomer contacts within the actin filament. Thus, the discovery of their role in nucleation was surprising. Here we use Drosophila Spire (Spir) as a model system to investigate both how ...[more]