Ontology highlight
ABSTRACT:
SUBMITTER: Pan Y
PROVIDER: S-EPMC4324438 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Pan Yi Y Carbe Christian C Kupich Sabine S Pickhinke Ute U Ohlig Stefanie S Frye Maike M Seelige Ruth R Pallerla Srinivas R SR Moon Anne M AM Lawrence Roger R Esko Jeffrey D JD Zhang Xin X Grobe Kay K
Matrix biology : journal of the International Society for Matrix Biology 20131105
Impaired heparan sulfate (HS) synthesis in vertebrate development causes complex malformations due to the functional disruption of multiple HS-binding growth factors and morphogens. Here, we report developmental heart defects in mice bearing a targeted disruption of the HS-generating enzyme GlcNAc N-deacetylase/GlcN N-sulfotransferase 1 (NDST1), including ventricular septal defects (VSD), persistent truncus arteriosus (PTA), double outlet right ventricle (DORV), and retroesophageal right subclav ...[more]