Ontology highlight
ABSTRACT:
SUBMITTER: Pegge J
PROVIDER: S-EPMC7196931 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Pegge James J Tatsinkam Arnold Junior AJ Rider Christopher C CC Bell Esther E
Developmental biology 20191225 2
Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at the neural plate border. Gremlin 1 (Grem1) is a secreted BMP antagonist expressed in the neural crest in Xenopus laevis but its function here is unknown. As well as binding BMPs, Grem1 has been shown to ...[more]