Ontology highlight
ABSTRACT:
SUBMITTER: Kalb D
PROVIDER: S-EPMC4325157 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Kalb Daniel D Heinekamp Thorsten T Lackner Gerald G Scharf Daniel H DH Dahse Hans-Martin HM Brakhage Axel A AA Hoffmeister Dirk D
Applied and environmental microbiology 20141219 5
The Aspergillus fumigatus nonribosomal peptide synthetase FtpA is among the few of this species whose natural product has remained unknown. Both FtpA adenylation domains were characterized in vitro. Fumaric acid was identified as preferred substrate of the first and both l-tyrosine and l-phenylalanine as preferred substrates of the second adenylation domain. Genetically engineered A. fumigatus strains expressed either ftpA or the regulator gene ftpR, encoded in the same cluster of genes, under t ...[more]