Ontology highlight
ABSTRACT:
SUBMITTER: Hyland PL
PROVIDER: S-EPMC4326067 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Hyland Paula L PL Pfeiffer Ruth M RM Rotunno Melissa M Hofmann Jonathan N JN Liu Chin-San CS Cheng Wen-Ling WL Yuenger Jeff J Lan Qing Q Tucker Margaret A MA Goldstein Alisa M AM Yang Xiaohong R XR
Journal of carcinogenesis & mutagenesis 20140601 Suppl 4
Quantitative changes in mitochondrial DNA (mtDNA) have been associated with the risk of a number of human cancers; however, the relationship between constitutive mtDNA copy number in blood and the risk of familial cutaneous malignant melanoma (CMM) has not been reported. We measured mtDNA copy number using quantitative PCR in blood-derived DNA from 136 CMM cases and 302 controls in 53 melanoma-prone families (23 segregating <i>CDKN2A</i> germline mutations). MtDNA copy number did not vary by age ...[more]