Ontology highlight
ABSTRACT:
SUBMITTER: Xia Y
PROVIDER: S-EPMC4326221 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Xia Yifeng Y Liu Yi-Liang YL Xie Yonghua Y Zhu Wei W Guerra Francisco F Shen Shen S Yeddula Narayana N Fischer Wolfgang W Low William W Zhou Xiaoying X Zhang Yonghui Y Oldfield Eric E Verma Inder M IM
Science translational medicine 20141101 263
Lung cancer is the most common human malignancy and leads to about one-third of all cancer-related deaths. Lung adenocarcinomas harboring KRAS mutations, in contrast to those with EGFR and EML4-ALK mutations, have not been successfully targeted. We describe a combination therapy for treating these malignancies with two agents: a lipophilic bisphosphonate and rapamycin. This drug combination is much more effective than either agent acting alone in the KRAS G12D-induced mouse lung model. Lipophili ...[more]