Ontology highlight
ABSTRACT:
SUBMITTER: Levy O
PROVIDER: S-EPMC4328649 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Levy Olivier O Calippe Bertrand B Lavalette Sophie S Hu Shulong J SJ Raoul William W Dominguez Elisa E Housset Michael M Paques Michel M Sahel José-Alain JA Bemelmans Alexis-Pierre AP Combadiere Christophe C Guillonneau Xavier X Sennlaub Florian F
EMBO molecular medicine 20150201 2
Physiologically, the retinal pigment epithelium (RPE) expresses immunosuppressive signals such as FAS ligand (FASL), which prevents the accumulation of leukocytes in the subretinal space. Age-related macular degeneration (AMD) is associated with a breakdown of the subretinal immunosuppressive environment and chronic accumulation of mononuclear phagocytes (MPs). We show that subretinal MPs in AMD patients accumulate on the RPE and express high levels of APOE. MPs of Cx3cr1(-/-) mice that develop ...[more]