EBV noncoding RNA binds nascent RNA to drive host PAX5 to viral DNA.
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ABSTRACT:
SUBMITTER: Lee N
PROVIDER: S-EPMC4329084 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
EBV noncoding RNA binds nascent RNA to drive host PAX5 to viral DNA.
Lee Nara N Moss Walter N WN Yario Therese A TA Steitz Joan A JA
Cell 20150205 4
EBER2 is an abundant nuclear noncoding RNA expressed by the Epstein-Barr virus (EBV). Probing its possible chromatin localization by CHART revealed EBER2's presence at the terminal repeats (TRs) of the latent EBV genome, overlapping previously identified binding sites for the B cell transcription factor PAX5. EBER2 interacts with PAX5 and is required for the localization of PAX5 to the TRs. EBER2 knockdown phenocopies PAX5 depletion in upregulating the expression of LMP2A/B and LMP1, genes neare ...[more]
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