Ontology highlight
ABSTRACT:
SUBMITTER: Tiwari R
PROVIDER: S-EPMC4329575 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Tiwari Rohit R Miller Patricia A PA Cho Sanghyun S Franzblau Scott G SG Miller Marvin J MJ
ACS medicinal chemistry letters 20141129 2
The discovery of 1,3-benzothiazin-4-ones (BTZs), especially BTZ043 and PBTZ-169 as potent agents for the treatment of tuberculosis, prompted intensive research related to development of potential antituberculosis agents based on electron deficient nitroaromatic scaffolds. Herein we report the syntheses, computational and NMR studies and anti-TB activity of oxidation products, 1,3-benzothiazinone sulfoxide (BTZ-SO) and 1,3-benzothiazinone sulfone (BTZ-SO2) derived from BTZ043. The combined comput ...[more]