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Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from Ex-RAD.

ABSTRACT: In this work, a series of novel benzyl naphthyl sulfoxides (sulfones) derived from Ex-RAD were designed and synthesized as potential radioprotective agents. Some of the compounds considerably protected HUVECs against 60Co ?-irradiation, accompanied by the absence of cytotoxicity. Compared to Ex-RAD, compound 8n not only exhibited a significant protective effect on cell survival and radiation-induced DNA damage, but also remarkably enhanced the survival (100%) of mice in 30 days after being exposed to irradiation. The results suggested that some target compounds are valuable for further research as promising radioprotectors.

SUBMITTER: Tang L

PROVIDER: S-EPMC6072350 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from Ex-RAD.

Tang Lin L Peng Tao T Wang Gang G Wen Xiaoxue X Sun Yunbo Y Zhang Shouguo S Liu Shuchen S Wang Lin L

MedChemComm 20180219 4

In this work, a series of novel benzyl naphthyl sulfoxides (sulfones) derived from Ex-RAD were designed and synthesized as potential radioprotective agents. Some of the compounds considerably protected HUVECs against <sup>60</sup>Co γ-irradiation, accompanied by the absence of cytotoxicity. Compared to Ex-RAD, compound <b>8n</b> not only exhibited a significant protective effect on cell survival and radiation-induced DNA damage, but also remarkably enhanced the survival (100%) of mice in 30 days ...[more]

PMID: 30108953

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