Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC4330785 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Li Youzhi Y Rogoff Harry A HA Keates Sarah S Gao Yuan Y Murikipudi Sylaja S Mikule Keith K Leggett David D Li Wei W Pardee Arthur B AB Li Chiang J CJ
Proceedings of the National Academy of Sciences of the United States of America 20150120 6
Partial or even complete cancer regression can be achieved in some patients with current cancer treatments. However, such initial responses are almost always followed by relapse, with the recurrent cancer being resistant to further treatments. The discovery of therapeutic approaches that counteract relapse is, therefore, essential for advancing cancer medicine. Cancer cells are extremely heterogeneous, even in each individual patient, in terms of their malignant potential, drug sensitivity, and ...[more]