Human ?-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
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ABSTRACT:
SUBMITTER: Chu H
PROVIDER: S-EPMC4332406 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Chu Hiutung H Pazgier Marzena M Jung Grace G Nuccio Sean-Paul SP Castillo Patricia A PA de Jong Maarten F MF Winter Maria G MG Winter Sebastian E SE Wehkamp Jan J Shen Bo B Salzman Nita H NH Underwood Mark A MA Tsolis Renee M RM Young Glenn M GM Lu Wuyuan W Lehrer Robert I RI Bäumler Andreas J AJ Bevins Charles L CL
Science (New York, N.Y.) 20120621 6093
Defensins are antimicrobial peptides that contribute broadly to innate immunity, including protection of mucosal tissues. Human α-defensin (HD) 6 is highly expressed by secretory Paneth cells of the small intestine. However, in contrast to the other defensins, it lacks appreciable bactericidal activity. Nevertheless, we report here that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo. After stochastic binding to bacterial surface proteins, HD6 undergoe ...[more]
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