Ontology highlight
ABSTRACT:
SUBMITTER: McHeyzer-Williams LJ
PROVIDER: S-EPMC4333102 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
McHeyzer-Williams Louise J LJ Milpied Pierre J PJ Okitsu Shinji L SL McHeyzer-Williams Michael G MG
Nature immunology 20150202 3
Effective vaccines induce high-affinity memory B cells and durable antibody responses through accelerated mechanisms of natural selection. Secondary changes in antibody repertoires after vaccine boosts suggest progressive rediversification of B cell receptors (BCRs), but the underlying mechanisms remain unresolved. Here, the integrated specificity and function of individual memory B cell progeny revealed ongoing evolution of polyclonal antibody specificities through germinal center (GC)-specific ...[more]