Ontology highlight
ABSTRACT:
SUBMITTER: Aiba Y
PROVIDER: S-EPMC2901464 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Aiba Yuichi Y Kometani Kohei K Hamadate Megumi M Moriyama Saya S Sakaue-Sawano Asako A Tomura Michio M Luche Hervé H Fehling Hans Jörg HJ Casellas Rafael R Kanagawa Osami O Miyawaki Atsushi A Kurosaki Tomohiro T
Proceedings of the National Academy of Sciences of the United States of America 20100614 27
It has long been presumed that after leaving the germinal centers (GCs), memory B cells colonize the marginal zone or join the recirculating pool. Here we demonstrate the preferential localization of nitrophenol-chicken gamma-globulin-induced CD38(+)IgG1(+) memory B cells adjacent to contracted GCs in the spleen. The memory B cells in this region proliferated after secondary immunization, a response that was abolished by depletion of CD4(+) T cells. We also found that these IgG1(+) memory B cell ...[more]