Ontology highlight
ABSTRACT:
SUBMITTER: Betts MJ
PROVIDER: S-EPMC4333368 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Betts Matthew J MJ Lu Qianhao Q Jiang YingYing Y Drusko Armin A Wichmann Oliver O Utz Mathias M Valtierra-Gutiérrez Ilse A IA Schlesner Matthias M Jaeger Natalie N Jones David T DT Pfister Stefan S Lichter Peter P Eils Roland R Siebert Reiner R Bork Peer P Apic Gordana G Gavin Anne-Claude AC Russell Robert B RB Russell Robert B RB
Nucleic acids research 20141111 2
Systematic interrogation of mutation or protein modification data is important to identify sites with functional consequences and to deduce global consequences from large data sets. Mechismo (mechismo.russellab.org) enables simultaneous consideration of thousands of 3D structures and biomolecular interactions to predict rapidly mechanistic consequences for mutations and modifications. As useful functional information often only comes from homologous proteins, we benchmarked the accuracy of predi ...[more]