Ontology highlight
ABSTRACT:
SUBMITTER: DuBois SG
PROVIDER: S-EPMC4333502 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
DuBois S G SG Allen S S Bent M M Hilton J F JF Hollinger F F Hawkins R R Courtier J J Mosse Y P YP Matthay K K KK
British journal of cancer 20150120 4
<h4>Background</h4>(131)I-metaiodobenzylguanidine (MIBG) is an active radiopharmaceutical in neuroblastoma. A previous study demonstrated that MIBG could be combined with vincristine and prolonged irinotecan, although 25% of first courses had grade 3 diarrhoea. The current phase I/II study evaluated MIBG with vincristine and 5 days of higher-dose irinotecan.<h4>Methods</h4>Patients 1-30 years old with advanced neuroblastoma were eligible. Patients received cefixime on days -1 to +6, irinotecan ( ...[more]