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Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization.

ABSTRACT: Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ?30,000- and ?20,000-fold at 9.4 T, corresponding to ?10% and ?7% nuclear spin polarization, respectively. This method, dubbed "SABRE in shield enables alignment transfer to heteronuclei" or "SABRE-SHEATH", promises to be a simple, cost-effective way to hyperpolarize heteronuclei. It may be particularly useful for in vivo applications because of longer hyperpolarization lifetimes, lack of background signal, and facile chemical-shift discrimination of different species.

SUBMITTER: Theis T

PROVIDER: S-EPMC4333583 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization.

Theis Thomas T Truong Milton L ML Coffey Aaron M AM Shchepin Roman V RV Waddell Kevin W KW Shi Fan F Goodson Boyd M BM Warren Warren S WS Chekmenev Eduard Y EY

Journal of the American Chemical Society 20150126 4

Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ∼30,000- and ∼20,000-fold at 9.4 T, corresponding to ∼10% and ∼7% nuclea ...[more]

PMID: 25583142

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