Ontology highlight
ABSTRACT:
SUBMITTER: Boban M
PROVIDER: S-EPMC4333764 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Boban Mirta M Pantazopoulou Marina M Schick Anna A Ljungdahl Per O PO Foisner Roland R
Journal of cell science 20140613 Pt 16
The nuclear envelope consists of inner and outer nuclear membranes. Whereas the outer membrane is an extension of the endoplasmic reticulum, the inner nuclear membrane (INM) represents a unique membranous environment containing specific proteins. The mechanisms of integral INM protein degradation are unknown. Here, we investigated the turnover of Asi2, an integral INM protein in Saccharomyces cerevisiae. We report that Asi2 is degraded by the proteasome independently of the vacuole and that it e ...[more]