Ontology highlight
ABSTRACT:
SUBMITTER: Premnath PN
PROVIDER: S-EPMC4334226 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Premnath Padmavathy Nandha PN Craig Sandra N SN Liu Shu S Anderson Erin L EL Grigoroudis Asterios I AI Kontopidis George G Perkins Tracy L TL Wyatt Michael D MD Pittman Douglas L DL McInnes Campbell C
Journal of medicinal chemistry 20141217 1
The cyclin groove is an important recognition site for substrates of the cell cycle cyclin dependent kinases and provides an opportunity for highly selective inhibition of kinase activity through a non-ATP competitive mechanism. The key peptide residues of the cyclin binding motif have been studied in order to precisely define the structure-activity relationship for CDK kinase inhibition. Through this information, new insights into the interactions of peptide CDK inhibitors with key subsites of ...[more]