Ontology highlight
ABSTRACT:
SUBMITTER: Derewacz DK
PROVIDER: S-EPMC4334282 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Derewacz Dagmara K DK McNees C Ruth CR Scalmani Giovanni G Covington Cody L CL Shanmugam Ganesh G Marnett Lawrence J LJ Polavarapu Prasad L PL Bachmann Brian O BO
Journal of natural products 20140721 8
Culture extracts from the cave-derived actinomycete Nonomuraea specus were investigated, resulting in the discovery of a new S-bridged pyronaphthoquinone dimer and its monomeric progenitors designated hypogeamicins A-D (1-4). The structures were elucidated using NMR spectroscopy, and the relative stereochemistries of the pyrans were inferred using NOE and comparison to previously reported compounds. Absolute stereochemistry was determined using quantum chemical calculations of specific rotation ...[more]