Ontology highlight
ABSTRACT:
SUBMITTER: Eiring AM
PROVIDER: S-EPMC4334758 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Eiring Anna M AM Page Brent D G BDG Kraft Ira L IL Mason Clinton C CC Vellore Nadeem A NA Resetca Diana D Zabriskie Matthew S MS Zhang Tian Y TY Khorashad Jamshid S JS Engar Alexander J AJ Reynolds Kimberly R KR Anderson David J DJ Senina Anna A Pomicter Anthony D AD Arpin Carolynn C CC Ahmad Shazia S Heaton William L WL Tantravahi Srinivas K SK Todic Aleksandra A Moriggl Richard R Wilson Derek J DJ Baron Riccardo R O'Hare Thomas T Gunning Patrick T PT Deininger Michael W MW
Leukemia 20140819 3
Mutations in the BCR-ABL1 kinase domain are an established mechanism of tyrosine kinase inhibitor (TKI) resistance in Philadelphia chromosome-positive leukemia, but fail to explain many cases of clinical TKI failure. In contrast, it is largely unknown why some patients fail TKI therapy despite continued suppression of BCR-ABL1 kinase activity, a situation termed BCR-ABL1 kinase-independent TKI resistance. Here, we identified activation of signal transducer and activator of transcription 3 (STAT3 ...[more]