Ontology highlight
ABSTRACT:
SUBMITTER: Chandramohanadas R
PROVIDER: S-EPMC4334792 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Chandramohanadas Rajesh R Basappa Russell Bruce B Liew Kingsley K Yau Yin Hoe YH Chong Alvin A Liu Min M Gunalan Karthigayan K Raman Rahul R Renia Laurent L Nosten Francois F Shochat Susana Geifman SG Dao Ming M Sasisekharan Ram R Suresh Subra S Preiser Peter P
The Journal of infectious diseases 20140526 10
Malaria causes nearly 1 million deaths annually. Recent emergence of multidrug resistance highlights the need to develop novel therapeutic interventions against human malaria. Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to identify such proteins as targets of small glycans. Combining multidisciplinary approaches, we report the discovery of a small molecule inhibitor, NIC, capable of inhibiting host invasion through interacting with a major invasion-rel ...[more]