Induced expression of Fc?RIIIa (CD16a) on CD4+ T cells triggers generation of IFN-?high subset.
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ABSTRACT:
SUBMITTER: Chauhan AK
PROVIDER: S-EPMC4335247 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
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Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
Chauhan Anil K AK Chen Chen C Moore Terry L TL DiPaolo Richard J RJ
The Journal of biological chemistry 20150102 8
Whether or not CD4(+) T-cells express low affinity receptor FcγRIIIa (CD16a) in disease pathology has not been examined in great detail. In this study, we show that a subset of activated CD4(+) T-cells in humans express FcγRIIIa. The ligation of FcγRIIIa by immune complexes (ICs) in human CD4(+) T-cells produced co-stimulatory signal like CD28 that triggered IFN-γ production. The induced expression of FcγRIIIa on CD4(+) helper T-cells is an important finding since these receptors via ITAM contri ...[more]
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