Ontology highlight
ABSTRACT:
SUBMITTER: Godefroy E
PROVIDER: S-EPMC4336179 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Cell reports 20141126 5
Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism underlying DC activation includes physical association with Toll-like receptor-2 (TLR2), leading to NF-κB activation, OX40L upregulation on DCs, and ensuing TH2 differentiation. Significantly, MMP-2 polarizes T ce ...[more]