Ontology highlight
ABSTRACT:
SUBMITTER: Holmes DA
PROVIDER: S-EPMC4337062 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Holmes Derek A DA Yeh Jung-Hua JH Yan Donghong D Xu Min M Chan Andrew C AC
The EMBO journal 20141114 2
Mitogen-activated protein kinase (MAPK) activation controls diverse cellular functions including cellular survival, proliferation, and apoptosis. Tuning of MAPK activation is counter-regulated by a family of dual-specificity phosphatases (DUSPs). IL-33 is a recently described cytokine that initiates Th2 immune responses through binding to a heterodimeric IL-33Rα (ST2L)/IL-1α accessory protein (IL-1RAcP) receptor that coordinates activation of ERK and NF-κB pathways. We demonstrate here that DUSP ...[more]