Neonatal neurobehavior effects following buprenorphine versus methadone exposure.

ABSTRACT:

Aim

To determine the effects of in utero exposure to methadone or buprenorphine on infant neurobehavior.

Design

Three sites from the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a double-blind, double-dummy, randomized clinical trial participated in this substudy.

Setting

Medical Centers that provided comprehensive maternal care to opioid-dependent pregnant women in Baltimore, MD, Providence, RI and Vienna, Austria.

Participants

Thirty-nine full-term infants.

Measurements

The Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale (NNNS) was administered to a subgroup of infants on postpartum days 3, 5, 7, 10, 14-15 and 28-30.

Findings

While neurobehavior improved for both medication conditions over time, infant

SUBMITTER: Coyle MG 

PROVIDER: S-EPMC4337995 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature