Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.
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ABSTRACT:
SUBMITTER: Lynagh T
PROVIDER: S-EPMC4338433 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.
Lynagh Timothy T Beech Robin N RN Lalande Maryline J MJ Keller Kevin K Cromer Brett A BA Wolstenholme Adrian J AJ Laube Bodo B
Scientific reports 20150224
Glutamate is an indispensable neurotransmitter, triggering postsynaptic signals upon recognition by postsynaptic receptors. We questioned the phylogenetic position and the molecular details of when and where glutamate recognition arose in the glutamate-gated chloride channels. Experiments revealed that glutamate recognition requires an arginine residue in the base of the binding site, which originated at least three distinct times according to phylogenetic analysis. Most remarkably, the arginine ...[more]
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