Ontology highlight
ABSTRACT:
SUBMITTER: Delaneau O
PROVIDER: S-EPMC4338501 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Delaneau Olivier O Marchini Jonathan J
Nature communications 20140613
A major use of the 1000 Genomes Project (1000 GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can ...[more]