Ontology highlight
ABSTRACT:
SUBMITTER: Nikolaev S
PROVIDER: S-EPMC4338529 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nikolaev Sergey S Santoni Federico F Garieri Marco M Makrythanasis Periklis P Falconnet Emilie E Guipponi Michel M Vannier Anne A Radovanovic Ivan I Bena Frederique F Forestier Françoise F Schaller Karl K Dutoit Valerie V Clement-Schatlo Virginie V Dietrich Pierre-Yves PY Antonarakis Stylianos E SE
Nature communications 20141204
Alteration of the number of copies of double minutes (DMs) with oncogenic EGFR mutations in response to tyrosine kinase inhibitors is a novel adaptive mechanism of glioblastoma. Here we provide evidence that such mutations in DMs, called here amplification-linked extrachromosomal mutations (ALEMs), originate extrachromosomally and could therefore be completely eliminated from the cancer cells. By exome sequencing of seven glioblastoma patients we reveal ALEMs in EGFR, PDGFRA and other genes. The ...[more]