New genetic loci link adipose and insulin biology to body fat distribution.
Ontology highlight
ABSTRACT:
SUBMITTER: Shungin D
PROVIDER: S-EPMC4338562 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
New genetic loci link adipose and insulin biology to body fat distribution.
Shungin Dmitry D Winkler Thomas W TW Croteau-Chonka Damien C DC Ferreira Teresa T Locke Adam E AE Mägi Reedik R Strawbridge Rona J RJ Pers Tune H TH Fischer Krista K Justice Anne E AE Workalemahu Tsegaselassie T Wu Joseph M W JMW Buchkovich Martin L ML Heard-Costa Nancy L NL Roman Tamara S TS Drong Alexander W AW Song Ci C Gustafsson Stefan S Day Felix R FR Esko Tonu T Fall Tove T Kutalik Zoltán Z Luan Jian'an J Randall Joshua C JC Scherag André A Vedantam Sailaja S Wood Andrew R AR Chen Jin J Fehrmann Rudolf R Karjalainen Juha J Kahali Bratati B Liu Ching-Ti CT Schmidt Ellen M EM Absher Devin D Amin Najaf N Anderson Denise D Beekman Marian M Bragg-Gresham Jennifer L JL Buyske Steven S Demirkan Ayse A Ehret Georg B GB Feitosa Mary F MF Goel Anuj A Jackson Anne U AU Johnson Toby T Kleber Marcus E ME Kristiansson Kati K Mangino Massimo M Leach Irene Mateo IM Medina-Gomez Carolina C Palmer Cameron D CD Pasko Dorota D Pechlivanis Sonali S Peters Marjolein J MJ Prokopenko Inga I Stančáková Alena A Sung Yun Ju YJ Tanaka Toshiko T Teumer Alexander A Van Vliet-Ostaptchouk Jana V JV Yengo Loïc L Zhang Weihua W Albrecht Eva E Ärnlöv Johan J Arscott Gillian M GM Bandinelli Stefania S Barrett Amy A Bellis Claire C Bennett Amanda J AJ Berne Christian C Blüher Matthias M Böhringer Stefan S Bonnet Fabrice F Böttcher Yvonne Y Bruinenberg Marcel M Carba Delia B DB Caspersen Ida H IH Clarke Robert R Daw E Warwick EW Deelen Joris J Deelman Ewa E Delgado Graciela G Doney Alex Sf AS Eklund Niina N Erdos Michael R MR Estrada Karol K Eury Elodie E Friedrich Nele N Garcia Melissa E ME Giedraitis Vilmantas V Gigante Bruna B Go Alan S AS Golay Alain A Grallert Harald H Grammer Tanja B TB Gräßler Jürgen J Grewal Jagvir J Groves Christopher J CJ Haller Toomas T Hallmans Goran G Hartman Catharina A CA Hassinen Maija M Hayward Caroline C Heikkilä Kauko K Herzig Karl-Heinz KH Helmer Quinta Q Hillege Hans L HL Holmen Oddgeir O Hunt Steven C SC Isaacs Aaron A Ittermann Till T James Alan L AL Johansson Ingegerd I Juliusdottir Thorhildur T Kalafati Ioanna-Panagiota IP Kinnunen Leena L Koenig Wolfgang W Kooner Ishminder K IK Kratzer Wolfgang W Lamina Claudia C Leander Karin K Lee Nanette R NR Lichtner Peter P Lind Lars L Lindström Jaana J Lobbens Stéphane S Lorentzon Mattias M Mach François F Magnusson Patrik Ke PK Mahajan Anubha A McArdle Wendy L WL Menni Cristina C Merger Sigrun S Mihailov Evelin E Milani Lili L Mills Rebecca R Moayyeri Alireza A Monda Keri L KL Mooijaart Simon P SP Mühleisen Thomas W TW Mulas Antonella A Müller Gabriele G Müller-Nurasyid Martina M Nagaraja Ramaiah R Nalls Michael A MA Narisu Narisu N Glorioso Nicola N Nolte Ilja M IM Olden Matthias M Rayner Nigel W NW Renstrom Frida F Ried Janina S JS Robertson Neil R NR Rose Lynda M LM Sanna Serena S Scharnagl Hubert H Scholtens Salome S Sennblad Bengt B Seufferlein Thomas T Sitlani Colleen M CM Smith Albert Vernon AV Stirrups Kathleen K Stringham Heather M HM Sundström Johan J Swertz Morris A MA Swift Amy J AJ Syvänen Ann-Christine AC Tayo Bamidele O BO Thorand Barbara B Thorleifsson Gudmar G Tomaschitz Andreas A Troffa Chiara C van Oort Floor Va FV Verweij Niek N Vonk Judith M JM Waite Lindsay L LL Wennauer Roman R Wilsgaard Tom T Wojczynski Mary K MK Wong Andrew A Zhang Qunyuan Q Zhao Jing Hua JH Brennan Eoin P EP Choi Murim M Eriksson Per P Folkersen Lasse L Franco-Cereceda Anders A Gharavi Ali G AG Hedman Åsa K ÅK Hivert Marie-France MF Huang Jinyan J Kanoni Stavroula S Karpe Fredrik F Keildson Sarah S Kiryluk Krzysztof K Liang Liming L Lifton Richard P RP Ma Baoshan B McKnight Amy J AJ McPherson Ruth R Metspalu Andres A Min Josine L JL Moffatt Miriam F MF Montgomery Grant W GW Murabito Joanne M JM Nicholson George G Nyholt Dale R DR Olsson Christian C Perry John Rb JR Reinmaa Eva E Salem Rany M RM Sandholm Niina N Schadt Eric E EE Scott Robert A RA Stolk Lisette L Vallejo Edgar E EE Westra Harm-Jan HJ Zondervan Krina T KT Amouyel Philippe P Arveiler Dominique D Bakker Stephan Jl SJ Beilby John J Bergman Richard N RN Blangero John J Brown Morris J MJ Burnier Michel M Campbell Harry H Chakravarti Aravinda A Chines Peter S PS Claudi-Boehm Simone S Collins Francis S FS Crawford Dana C DC Danesh John J de Faire Ulf U de Geus Eco Jc EJ Dörr Marcus M Erbel Raimund R Eriksson Johan G JG Farrall Martin M Ferrannini Ele E Ferrières Jean J Forouhi Nita G NG Forrester Terrence T Franco Oscar H OH Gansevoort Ron T RT Gieger Christian C Gudnason Vilmundur V Haiman Christopher A CA Harris Tamara B TB Hattersley Andrew T AT Heliövaara Markku M Hicks Andrew A AA Hingorani Aroon D AD Hoffmann Wolfgang W Hofman Albert A Homuth Georg G Humphries Steve E SE Hyppönen Elina E Illig Thomas T Jarvelin Marjo-Riitta MR Johansen Berit B Jousilahti Pekka P Jula Antti M AM Kaprio Jaakko J Kee Frank F Keinanen-Kiukaanniemi Sirkka M SM Kooner Jaspal S JS Kooperberg Charles C Kovacs Peter P Kraja Aldi T AT Kumari Meena M Kuulasmaa Kari K Kuusisto Johanna J Lakka Timo A TA Langenberg Claudia C Le Marchand Loic L Lehtimäki Terho T Lyssenko Valeriya V Männistö Satu S Marette André A Matise Tara C TC McKenzie Colin A CA McKnight Barbara B Musk Arthur W AW Möhlenkamp Stefan S Morris Andrew D AD Nelis Mari M Ohlsson Claes C Oldehinkel Albertine J AJ Ong Ken K KK Palmer Lyle J LJ Penninx Brenda W BW Peters Annette A Pramstaller Peter P PP Raitakari Olli T OT Rankinen Tuomo T Rao D C DC Rice Treva K TK Ridker Paul M PM Ritchie Marylyn D MD Rudan Igor I Salomaa Veikko V Samani Nilesh J NJ Saramies Jouko J Sarzynski Mark A MA Schwarz Peter Eh PE Shuldiner Alan R AR Staessen Jan A JA Steinthorsdottir Valgerdur V Stolk Ronald P RP Strauch Konstantin K Tönjes Anke A Tremblay Angelo A Tremoli Elena E Vohl Marie-Claude MC Völker Uwe U Vollenweider Peter P Wilson James F JF Witteman Jacqueline C JC Adair Linda S LS Bochud Murielle M Boehm Bernhard O BO Bornstein Stefan R SR Bouchard Claude C Cauchi Stéphane S Caulfield Mark J MJ Chambers John C JC Chasman Daniel I DI Cooper Richard S RS Dedoussis George G Ferrucci Luigi L Froguel Philippe P Grabe Hans-Jörgen HJ Hamsten Anders A Hui Jennie J Hveem Kristian K Jöckel Karl-Heinz KH Kivimaki Mika M Kuh Diana D Laakso Markku M Liu Yongmei Y März Winfried W Munroe Patricia B PB Njølstad Inger I Oostra Ben A BA Palmer Colin Na CN Pedersen Nancy L NL Perola Markus M Pérusse Louis L Peters Ulrike U Power Chris C Quertermous Thomas T Rauramaa Rainer R Rivadeneira Fernando F Saaristo Timo E TE Saleheen Danish D Sinisalo Juha J Slagboom P Eline PE Snieder Harold H Spector Tim D TD Stefansson Kari K Stumvoll Michael M Tuomilehto Jaakko J Uitterlinden André G AG Uusitupa Matti M van der Harst Pim P Veronesi Giovanni G Walker Mark M Wareham Nicholas J NJ Watkins Hugh H Wichmann H-Erich HE Abecasis Goncalo R GR Assimes Themistocles L TL Berndt Sonja I SI Boehnke Michael M Borecki Ingrid B IB Deloukas Panos P Franke Lude L Frayling Timothy M TM Groop Leif C LC Hunter David J DJ Kaplan Robert C RC O'Connell Jeffrey R JR Qi Lu L Schlessinger David D Strachan David P DP Thorsteinsdottir Unnur U van Duijn Cornelia M CM Willer Cristen J CJ Visscher Peter M PM Yang Jian J Hirschhorn Joel N JN Zillikens M Carola MC McCarthy Mark I MI Speliotes Elizabeth K EK North Kari E KE Fox Caroline S CS Barroso Inês I Franks Paul W PW Ingelsson Erik E Heid Iris M IM Loos Ruth Jf RJ Cupples L Adrienne LA Morris Andrew P AP Lindgren Cecilia M CM Mohlke Karen L KL
Nature 20150201 7538
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI) ...[more]