Brain insulin sensitivity is linked to adiposity and body fat distribution.
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ABSTRACT:
SUBMITTER: Kullmann S
PROVIDER: S-EPMC7160151 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Brain insulin sensitivity is linked to adiposity and body fat distribution.
Kullmann Stephanie S Valenta Vera V Wagner Robert R Tschritter Otto O Machann Jürgen J Häring Hans-Ulrich HU Preissl Hubert H Fritsche Andreas A Heni Martin M
Nature communications 20200415 1
Brain insulin action regulates eating behavior and energy fluxes throughout the body. However, numerous people are brain insulin resistant. How brain insulin responsiveness affects long-term weight and body fat composition in humans is still unknown. Here we show that high brain insulin sensitivity before lifestyle intervention associates with a more pronounced reduction in total and visceral fat during the program. High brain insulin sensitivity is also associated with less regain of fat mass d ...[more]
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