Ontology highlight
ABSTRACT:
SUBMITTER: Martin YN
PROVIDER: S-EPMC4338940 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Martin Yvette N YN Manlove Logan L Dong Jie J Carey William A WA Thompson Michael A MA Pabelick Christina M CM Pandya Hitesh C HC Martin Richard J RJ Wigle Dennis A DA Prakash Y S YS
American journal of physiology. Lung cellular and molecular physiology 20141114 2
Supplemental oxygen, used to treat hypoxia in preterm and term neonates, increases the risk of neonatal lung diseases, such as bronchopulmonary dysplasia (BPD) and asthma. There is a known sex predilection for BPD, but the underlying mechanisms are not clear. We tested the hypothesis that altered, local estradiol following hyperoxia contributes to pathophysiological changes observed in immature lung. In human fetal airway smooth muscle (fASM) cells exposed to normoxia or hyperoxia, we measured t ...[more]