Ontology highlight
ABSTRACT:
SUBMITTER: Sieck GC
PROVIDER: S-EPMC6739507 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Physiological reports 20190901 17
Airway diseases such as asthma are triggered by inflammation and mediated by proinflammatory cytokines such as tumor necrosis factor alpha (TNFα). Our goal was to systematically examine the potential mechanisms underlying the effect of TNFα on airway smooth muscle (ASM) contractility. Porcine ASM strips were incubated for 24 h with and without TNFα. Exposure to TNFα increased maximum ASM force in response to acetylcholine (Ach), with an increase in ACh sensitivity (hyperreactivity), as reflected ...[more]