Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC4339088 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Zhang Jiandong J Patel Mehul B MB Griffiths Robert R Mao Alice A Song Young-soo YS Karlovich Norah S NS Sparks Matthew A MA Jin Huixia H Wu Min M Lin Eugene E EE Crowley Steven D SD
Hypertension (Dallas, Tex. : 1979) 20140902 6
Immune system activation contributes to the pathogenesis of hypertension and the resulting progression of chronic kidney disease. In this regard, we recently identified a role for proinflammatory Th1 T-lymphocyte responses in hypertensive kidney injury. Because Th1 cells generate interferon-γ and tumor necrosis factor-α (TNF-α), we hypothesized that interferon-γ and TNF-α propagate renal damage during hypertension induced by activation of the renin-angiotensin system. Therefore, after confirming ...[more]