Ontology highlight
ABSTRACT:
SUBMITTER: Qin T
PROVIDER: S-EPMC4339264 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nature chemistry 20150202 3
Chiral, dimeric natural products containing complex structures and interesting biological properties have inspired chemists and biologists for decades. A seven-step total synthesis of the axially chiral, dimeric tetrahydroxanthone natural product rugulotrosin A is described. The synthesis employs a one-pot Suzuki coupling/dimerization to generate the requisite 2,2'-biaryl linkage. Highly selective point-to-axial chirality transfer was achieved using palladium catalysis with achiral phosphine lig ...[more]