Ontology highlight
ABSTRACT:
SUBMITTER: Dumortier JG
PROVIDER: S-EPMC4339552 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Dumortier Julien G JG David Nicolas B NB
PloS one 20150224 2
TORC2 is a serine-threonine kinase complex conserved through evolution that recently emerged as a new regulator of actin dynamics and cell migration. However, knockout in mice of its core components Sin1 and Rictor is embryonic lethal, which has limited in vivo analyses. Here, we analysed TORC2 function during early zebrafish development, using a morpholino-mediated loss of function of sin1. Sin1 appears required during gastrulation for migration of the prechordal plate, the anterior most mesode ...[more]