Ontology highlight
ABSTRACT:
SUBMITTER: Jaishy B
PROVIDER: S-EPMC4340303 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Jaishy Bharat B Zhang Quanjiang Q Chung Heaseung S HS Riehle Christian C Soto Jamie J Jenkins Stephen S Abel Patrick P Cowart L Ashley LA Van Eyk Jennifer E JE Abel E Dale ED
Journal of lipid research 20141221 3
Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific. Despite adverse consequences of obesity on cardiac structure and function, the contribution of altered cardiac autophagy in response to fatty acid overload is incompletely understood. Here, we report the suppression of autophagosome clearance and the activation of NADPH oxidase (Nox)2 in both high fat-fed murine hearts ...[more]