Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Z
PROVIDER: S-EPMC6778891 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhu Zhiyuan Z Zhang Pingde P Li Ning N Kiang Karrie Mei Yee KMY Cheng Stephen Yin SY Wong Vincent Kam-Wai VK Leung Gilberto Ka-Kit GK
BioMed research international 20190923
Drug resistance to temozolomide (TMZ) contributes to the majority of tumor recurrence and treatment failure in patients with glioblastoma multiforme (GBM). Autophagy has been reported to play a role in chemoresistance in various types of cancer, including GBM. The anticancer effect of statins is arousing great research interests and has been demonstrated to modulate autophagic function. In this study, we investigated the combinational effects of lovastatin and TMZ on treating U87 and U251 GBM ce ...[more]