Ontology highlight
ABSTRACT:
SUBMITTER: Taylor GS
PROVIDER: S-EPMC4340506 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Taylor Graham S GS Jia Hui H Harrington Kevin K Lee Lip Wai LW Turner James J Ladell Kristin K Price David A DA Tanday Manjit M Matthews Jen J Roberts Claudia C Edwards Ceri C McGuigan Lesley L Hartley Andrew A Wilson Steve S Hui Edwin P EP Chan Anthony T C AT Rickinson Alan B AB Steven Neil M NM
Clinical cancer research : an official journal of the American Association for Cancer Research 20140814 19
<h4>Purpose</h4>Epstein-Barr virus (EBV) is associated with several cancers in which the tumor cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost immunity to these tumor antigens. A phase I trial was conducted to demonstrate the safety and immunogenicity of MVA-EL across a range of doses.<h4>Experimental design</h4>Sixteen patients in the United Kingdom (UK) with EBV-positive nasopharyngeal carcinoma (NPC) recei ...[more]