Ontology highlight
ABSTRACT:
SUBMITTER: Saibil H
PROVIDER: S-EPMC4340576 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Nature reviews. Molecular cell biology 20130912 10
Molecular chaperones are diverse families of multidomain proteins that have evolved to assist nascent proteins to reach their native fold, protect subunits from heat shock during the assembly of complexes, prevent protein aggregation or mediate targeted unfolding and disassembly. Their increased expression in response to stress is a key factor in the health of the cell and longevity of an organism. Unlike enzymes with their precise and finely tuned active sites, chaperones are heavy-duty molecul ...[more]