Ontology highlight
ABSTRACT:
SUBMITTER: Nillegoda NB
PROVIDER: S-EPMC4830470 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Nillegoda Nadinath B NB Kirstein Janine J Szlachcic Anna A Berynskyy Mykhaylo M Stank Antonia A Stengel Florian F Arnsburg Kristin K Gao Xuechao X Scior Annika A Aebersold Ruedi R Guilbride D Lys DL Wade Rebecca C RC Morimoto Richard I RI Mayer Matthias P MP Bukau Bernd B
Nature 20150805 7564
Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states. Healthy metazoan cells effectively eliminate intracellular protein aggregates, indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazoans lack the key heat-shock protein disaggregase HSP100 of non-metazoan HSP70-dependent protein disaggregation systems, and the human HSP70 system alone, even with the crucial HSP110 nucleotide exchange factor, ...[more]