Ontology highlight
ABSTRACT:
SUBMITTER: Coelho C
PROVIDER: S-EPMC4340727 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Coelho Carolina C Souza Ana Camila Oliveira AC Derengowski Lorena da Silveira Lda S de Leon-Rodriguez Carlos C Wang Bo B Leon-Rivera Rosiris R Bocca Anamelia Lorenzetti AL Gonçalves Teresa T Casadevall Arturo A
Journal of immunology (Baltimore, Md. : 1950) 20150202 5
Human infection with Cryptococcus neoformans, a common fungal pathogen, follows deposition of yeast spores in the lung alveoli. The subsequent host-pathogen interaction can result in eradication, latency, or extrapulmonary dissemination. Successful control of C. neoformans infection is dependent on host macrophages, but macrophages display little ability to kill C. neoformans in vitro. Recently, we reported that ingestion of C. neoformans by mouse macrophages induces early cell cycle progression ...[more]