Ontology highlight
ABSTRACT:
SUBMITTER: Laperle A
PROVIDER: S-EPMC4340738 | biostudies-literature | 2015 Jan-Feb
REPOSITORIES: biostudies-literature
Laperle Alex A Masters Kristyn S KS Palecek Sean P SP
Biotechnology progress 20141028 1
Stem cells reside in specialized niches in vivo. Specific factors, including the extracellular matrix (ECM), in these niches are directly responsible for maintaining the stem cell population. During development, components of the stem cell microenvironment also control differentiation with precise spatial and temporal organization. The stem cell microenvironment is dynamically regulated by the cellular component, including stem cells themselves. Thus, a mechanism exists whereby stem cells modify ...[more]