Famine versus feast: understanding the metabolism of tumors in vivo.
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ABSTRACT:
SUBMITTER: Mayers JR
PROVIDER: S-EPMC4340757 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Famine versus feast: understanding the metabolism of tumors in vivo.
Mayers Jared R JR Vander Heiden Matthew G MG
Trends in biochemical sciences 20150129 3
To fuel unregulated proliferation, cancer cells alter metabolism to support macromolecule biosynthesis. Cell culture studies have revealed how different oncogenic mutations and nutrients impact metabolism. Glucose and glutamine are the primary fuels used in vitro; however, recent studies have suggested that utilization of other amino acids as well as lipids and protein can also be important to cancer cells. Early investigations of tumor metabolism are translating these findings to the biology of ...[more]
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