Ontology highlight
ABSTRACT:
SUBMITTER: Maurice D
PROVIDER: S-EPMC1949015 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Maurice Diane D Hooper Joel J Lang Georgina G Weston Kathleen K
The EMBO journal 20070719 15
During T-cell development, thymocytes with intermediate avidity for antigen-MHC complexes are positively selected and then differentiate into functional cytotoxic and helper T cells. This process is controlled by signalling from the T-cell receptor (TCR). Here, we show that the c-Myb transcription factor is a critical downstream regulator of positive selection, promoting the development of helper T cells and blocking the development of cytotoxic T cells. A gain-of-function c-Myb transgene stops ...[more]